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Recent Publications
Pace, J., Lee, J., Srinivasarao, M., Kallepu, S., Low, P., Niedre, M. (2024) “In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38″ Molecular Imaging Biology
Ivich, F., Calderon, I., Fang, Q., Clark, H., and Niedre, M., (2023) “Ratiometric fluorescence sensing and quantification of circulating blood sodium sensors in mice in vivo,” Biomed. Opt. Express 14, 5555-5568
Blaney, G., Ivich, F., Sassaroli, A., Niedre, M., Fantini S., (2023) “Dual-ratio approach for detection of point fluorophores in biological tissue,” J. Biomed. Opt. 28(7), 077001
Niedre, M., (2022) “Prospects for Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells in Humans,” Frontiers in Photonics 3
Pace, J.S., Ivich, F., Marple, E., Niedre, M. (2022) “Near-Infrared Diffuse In Vivo Flow Cytometry,” Journal of Biomedical Optics 27(9), 097002
Ivich F., Pace, J.S., Williams A.L., Shumel, M., Fang, Q., Niedre, M. (2022) “Signal and Measurement Considerations for Human Translation of Diffuse in vivo Flow Cytometry (DiFC)”. Journal of Biomedical Optics 27(6), 067001
Patil, R.A., Srinivasarao, M., Amiji, M.M, Low, P.S, Niedre, M. (2020) “Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry”. Molecular Imaging Bioliology 22, 1280–1289
Williams, A.L., Fitzgerald ,J.E., Ivich F., Sontag, E.D., Niedre, M. (2020) “Short-Term Circulating Tumor Cell Dynamics in Mouse Xenograft Models and Implications for Liquid Biopsy”. Frontiers in Oncology, 10(2447)
Fitzgerald, J.E., Byrd, B.K., Patil, R.A., Strawbridge, R.R., Davis, S.C., Bellini, C., and Niedre, M. (2020) “Heterogeneity of Circulating Tumor Cell Dynamics and Lung Metastases in a Subcutaneous Lewis Lung Carcinoma Model,” Biomedical Optics Express, 11(7), 395289Patil R., Srinivasarao, M., Amiji, M., Low, P.S. and Niedre, M. (2020), “Fluorescence labeling of circulating tumor cells with a folate receptor targeted molecular probe for diffuse in vivo flow cytometry,” Molecular Imaging and Biology, epub 09 June 2020.
Di, W., Tan, X., Calderon, I.A., Reilly, A.N., Niedre, M. and Clark, H. (2020), “Real-time particle-by-particle detection of erythrocyte camouflaged microsensor with extended circulation time in the bloodstream,” Proceedings of the National Academy of Sciences USA,117(7):3509-3517.
Mensah, S.A., Nersesyan, A.A., Harding, I.C., Lee, C.I., Tan, X., Banerjee, S., Niedre, M., Torchilin, V.P. and Ebong, E.E. (2020), “Flow‐regulated endothelial glycocalyx determines metastatic cancer cell activity,” FASEB Journal, Mar 13.
Bartosik, P., Fitzgerald, J., El Khatib, M., Yaseen, M.A., Vinogradov, S.A. and Niedre, M. (2020), “Prospects for use of upconverting nanoparticles as a contrast agent for enumeration of circulating tumor cells in vivo,”International Journal of Nanomedicine,15:1709-1719.
Patil R., Tan, X., Bartosik, P., Detappe A., Runnels, J., Ghobrial I., Lin C.P. and Niedre, M. (2019) “In vivo monitoring of rare circulating tumor cell and cluster dissemination in a multiple myeloma xenograft model,” Journal of Biomedical Optics, 24(8), 085004.
Mensah, S.A., Harding, I.C., Zhang, M., Jaeggli, M.P., Torchilin, V.P., Niedre, M. and Ebong, E.E. (2019) “Metastatic cancer cell attachment to endothelium is promoted by endothelial glycocalyx sialic acid degredation,” AIChE Journal,65(8) e16634.
Tan, X., Patil R., Bartosik, P., Runnels, J., Lin C.P. and Niedre, M. (2019) “Ultra-rare in vivo flow cytometry,” Scientific Reports,9(1):3366
Draghici, A.E., Potart, D., Hollmann, J.L., Pera, V., Fang Q, DiMarzio CA, Taylor, J.A., Niedre, M.J. and Shefelbine, S.J. (2018) “Near infrared spectroscopy for measuring changes in bone hemoglobin content after exercise in individuals
Hartmann, C., Patil, R., Lin, C.P. and Niedre, M. (2017) “Fluorescence detection, enumeration and characterization of single circulating cells in vivo: Technology, applications and future prospects”, Physics in Medicine and Biology, 63 (1), 01TR01
Pera, V.*, Tan, X*, Runnels, J., Sardesai, N., Lin, C.P. and Niedre, M. (2017) “Diffuse fluorescence fiber probe for in vivo detection of circulating tumor cells” Journal of Biomedical Optics 22(3): 37004
*equal contributors to the paper
Mu, Y., Pera, V. and Niedre, M. (2016) “Multiplexed fluorescence mediated tomography with temporal and spectral data” Journal of Biomedical Optics 21(10):105001.
Markovic, S., Belz, J., Kumar, R., Cormack, R.A., Sridhar, S. and Niedre, M. (2016) “Near-infrared fluorescence imaging platform for quantifying in vivo nanoparticle diffusion from drug loaded implants” International Journal of Nanomedicine 11 1213-1223.
Pera, V., Brooks, D.H. and Niedre, M. (2015) “Multiplexed fluorescence tomography with spectral and temporal data: demixing with intrinsic regularization” Biomedical Optics Express 7(1) 111-131.
Mu, Y. and Niedre, M. (2015) “A fast single photon avalanche photodiode-based time-resolved diffuse optical tomography scanner” Biomedical Optics Express 6(9) 3596-3609.
Pera, V., Brooks, D.H. and Niedre, M. (2015) “A sparse nonnegative demixing algorithm with intrinsic regularization for multiplexed fluorescence tomography” IEEE 12th International Symposium on Biomedical Imaging 1044-1047.Markovic, S., Li, S. and Niedre, M. (2015) “Performance of computer vision in vivo flow cytometry with low fluorescence contrast” Journal of Biomedical Optics 20(3):35005.
Kumar, R., Belz, J., Markovic, S., Jadhav, T., Fowle, W., Niedre, M., Cormack, R., Makrigiorgos, M.G. and Sridhar, S. (2015) “Nanoparticle-based brachytherapy spacers for delivery of localized combined chemoradiation therapy” International Journal Radiation Oncology Biology and Physics 91(2):393-400.
Markovic, S., Li, S., Zhang, T. and Niedre, M. (2014) “Toward lower contrast computer vision in vivo flow cytometry” Conf Proc IEEE Eng Med Biol Soc.
Mu, Y. and Niedre, M. (2014) “A fast SPAD-based small animal imager for early-photon diffuse optical tomography” Conf Proc IEEE Eng Med Biol Soc.
Pera, V., Brooks, D.H. and Niedre, M. (2014) “On the use of Cramer-Rao Bounds in diffuse optical tomography” Journal of Biomedical Optics, 19(2):025002.
Markovic, S., Li, B., Pera, V., Sznaier, M., Camps, O. and Niedre, M. (2013) “A computer vision approach to rare cell in vivo flow cytometry” Cytometry A, 83A: 1113-1123.
Pera, V., Zettergren, E., Brooks, D.H. and Niedre, M. (2013) “Maximum likelihood tomographic reconstruction of extremely sparse solutions in diffuse fluorescence flow cytometry” Optics Letters 38(12):2098-2100.
Pestana, N., Mortensen, L., Runnels, J., Vickers, D. Murthy, S.K., Lin, C.P. Niedre, M. (2013) “An improved prototype diffuse fluorescence flow cytometer for high sensitivity detection of rare circulating cells in vivo” Journal of Biomedical Optics 18(7):77002.
Mu, Y., Valim, N. and Niedre, M. (2013) “Evaluation of a fast single-photon avalanche photodiode for measurement of early transmitted photons through diffusive media” Optics Letters 38(12): 2098-2100.
Pestana, N., Walsh, D., Hatch, A. Jaffe, G., Hahn, P., Murthy, S.K. Niedre, M. (2013) “A dedicated low-cost fluorescence microfluidic device reader for point-of-care ocular diagnostics” Journal of Medical Devices 7(2): 024501.
Valim, N., Brock, J., Leeser, M., Niedre, M. (2013) “The effect of temporal impulse response on experimental reduction of photon scatter in time-resolved diffuse optical tomography” Physics in Medicine and Biology 58(2):335-349.
Dimarzio, C.A. and Niedre, M. (2012) “Pre-clinical optical molecular imaging in the lung: Technological challenges and future prospects” Journal of Thoracic Disease 4(6):556-557.
Zettergren, E., Swamy, T., Runnels, J., Lin, C.P., Niedre M. (2012) “Tomographic sensing and localization of fluorescently labeled circulating cells in mice in vivo” Physics in Medicina and Biology 57(14):4627-4641.
Zettergren, E., Vickers, D., Runnels, J., Murthy S.K., Lin C.P. and Niedre, M. (2012) “Instrument for fluorescence sensing of circulating cells with diffuse light in mice in vivo” Journal of Biomedical Optics 17(3):037001.
Valim, N. and Niedre, M. (2012) “Instrumentation considerations for measurement of early arriving photons in diffuse optical tomography” Proceedings of the SPIE, Design and Quality for Biomedical Technologies V, Vol 8215
Li, Z. and Niedre, M. (2011) “Hybrid use of early and quasi-continuous wave photons in time-domain tomographic imaging for improved resolution and quantitative accuracy” Biomedical Optics Express; 23:665-679.
Zettergren, E., Vickers, D. and Niedre, M. (2011) “Sensing and enumerating rare circulating cells with diffuse light” Proceedings of the SPIE, Imaging, Manipulation and Analysis of Biomolecules, Cells and Tissues IX Vol 7902.
Jarvi, M.T., Niedre, M.J., Patterson, M.S. and Wilson, B.C. (2011) “The influence of oxygen depletion and photosensitizer triplet-state dynamics during photodynamic therapy on accurate singlet oxygen luminescence monitoring and analysis of treatment dose response” Photochemistry and Photobiology 87(1):223-234.
Valim, N., Brock, J. and Niedre, M.J. (2010) “Experimental measurement of time-dependent photon scatter for diffuse optical tomography” Journal of Biomedical Optics 15(6):065006. Niedre, M.J. and Ntziachristos, V. (2010) “Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi continuous-wave photons” Optics Letters 35:369-371.
Patents
US Patent: “Systems and methods for sensing, enumerating and imaging rare cells with diffuse light” US9968259
Filed: January 24 2013, Issued May 15, 2018
Inventors: Mark Niedre, Eric Zettergren, Charles P. Lin,
US Patent: “Systems and methods for optical imaging using early-arriving photons” US8314406 B2
Filed: Apr 4, 2008, Issued Nov 20, 2012. Inventors: Vasilis Ntziachristos, Mark Niedre